Endocrine Abstracts

GPR120 is a rhodopsin-like GPCR that has a high affinity for long-chain saturated fatty acids 14–18 carbons and unsaturated fatty acids 16–22 carbons. The beneficial effects of GPR120 on β-cell function and glucose homeostasis have recently been reported however its role in glucagon secretion is unknown. GPR120 and glucagon expression were examined by double immunohistochemical studies using a glucagon secreting cell line (α-TC1.9) and pancreatic tissue fro...

Aims: Glycated insulin exhibits impaired glucose-lowering ability and increasing evidence supports a role for glycation of insulin in the insulin resistant state of Type 2 diabetes. We used a novel radioimmunoassay to evaluate the effect of the insulin secretagogue nateglinide on plasma glycated insulin in Type 2 diabetes. Methods: Ten patients (5M/5F, age 57.8±1.9 years, HbA1c 7.6±0.5%, fasting plasma glucose 9.4±1.2millimols per litre, creatinine 81.6&pl...

Aims: Increasing evidence supports the role of glycated insulin in the insulin resistant state of type 2 diabetes. We measured 24-hour profiles of plasma glycated insulin, using a novel radioimmunoassay, to evaluate the effects of meal stimulated insulin secretion and the fasting state on production of plasma glycated insulin in type 2 diabetes. Methods: Patients (n=6, HbA1c 7.2±0.6%, fasting plasma glucose 7.4±0.7 mmol l-1, BMI 35.7±3.5 kg m<su...